A major fire has killed at least two people and injured others at the four star Eurostars David hotel in the centre of the city. People are still stuck in the smoking building waiting to be evacuated, according to local reports. "There are two (deaths) but we are afraid that won't be the final figure," Petr Kolouch, director of the Prague Emergency Medical Service, told Czech Television. He said that smoke suffocated or poisoned the dead but they did not burn alive. Others are now being treated for smoke inhalation. Two firefighters are among the injured after they fell while tending to the blaze, Lidovky.cz reports. "It's not burning anymore, but the hotel is still very hot and smoky. "We are still searching for people," Prague fire brigade spokesman Martin Kavka told Lidovky.cz. "We'll be here for several more hours," he added. The cause of the fire is not yet known. One firefighter told local media that the blaze broke out on the ground floor and the smoke permeated the entire building. At least 16 firefighting units and a police helicopter are at the scene, it has been reported. The Czech Fire Rescue Service said that forty people were evacuated from the hotel, which is located near the Vltava River and the Czech capital's National Theatre.